Principal Investigator Dr. J.H. (Jorke) Kamstra from our partner University of Utrecht presented a project poster titled “Investigation of Endocrine Disrupting Chemicals (EDCs) as Contributors to the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD),” at the 46th NVT Annual Meeting (Dutch Society of Toxicology) 2024, held in Ede, Netherlands.
The research focused on how EDCs contribute to the progression of MASLD, highlighting how these chemicals interfere with metabolic processes and reprogram hepatic lipid homeostasis. The poster presented genetic insights, showcasing evidence from recent data indicating the role of specific genes in MASLD. A multi-omics approach was utilized, including metabolomics, lipidomics, proteomics, transcriptomics, and epigenetics, to study the effects of EDCs comprehensively. Various experimental models, such as 2D/3D, murine, and zebrafish transgenic models, were employed to investigate the impacts on liver health. Additionally, the research mapped adverse outcome pathways through systems toxicology and discussed the policy implications, emphasizing the need for regulatory measures to mitigate EDC exposure and protect liver health.
